Some months ago I faced the need to use a uniform folder structure that spanned across numerous sites of an enterprise to be used as a common repository for the Software packages of the Configuration Manager 2007 infrastructure.
Because the procedure was relatively lengthy and the final outcome was extremely good, i started compiling a guide for the setup of a DFS structure for Software Distribution via the Configuration Manager and bundled it with the Office 2007 deployment package instructions.
The instructions were written for a Windows 2008 Server but can be used on Windows 2003 R2 and Windows 2008 R2 Servers.
Keep in mind that this is not the official recommended way and Microsoft doesn’t support it.
You may download the file from my SkyDrive by clicking the following linked title: Deploying software that resides in DFS Folders via Configuration Manager 2007
Hope it helps as it did for me!